Shedding: What is viral excretion? シェディング：ウィルス排泄とは？

シェディング：ウィルス排泄とは？←日本語版はこちら

What is the topic of shedding in relation to replicon vaccines?

The following is a reprint of a text by Shuichi Aoshima in response to the Japan Society of Nursing Ethics' "Concerns about replicon vaccines being introduced for COVID-19 vaccinations: for yourself and those around you," stating that the statement lacks scientific evidence.

The concept of shedding has been drawing attention as a concern regarding the safety of Costaibe.

Generally, shedding means viral excretion, and is considered to be the process in which the virus replicates in the infected person's body and is released from the body via the respiratory system (coughing and sneezing), digestive system (feces), and bodily fluids (blood, saliva, urine, etc.).

The emergency statement released by the Japan Society of Nursing Ethics strongly refers to the issue of Costaibe and shedding1). However, there are few academic documents that discuss the phenomenon known as shedding in detail. The statement also states, "Because the replicon vaccine is a 'self-replicating mRNA,' there is concern that the replicon vaccine itself may be transmitted (shedding) from the vaccinated person to the non-vaccinated person," but does not clearly define shedding.

The statement continues, "That is, it raises the ethical issue of vaccine components being ingested by unwilling individuals," and from the context, it seems to mean that the active ingredients in the vaccine are transmitted from vaccinated individuals to non-vaccinated individuals.

Can sewage reveal the spread of SARS-CoV-2?

SARS-CoV-2 peaks within five days of the onset of symptoms or diagnosis, and takes 10 to 17 days to cease being excreted2). It is also known to proliferate not only in the upper respiratory tract of humans, but also in the intestinal tract.

Since the virus contained in feces and saliva flows into sewage treatment plants through sewage pipes, the spread of the new coronavirus can be grasped by measuring the viral RNA from running water samples. This type of epidemiological survey using sewage is called sewage surveillance3).

When a global pandemic actually occurred, sewage surveillance was carried out in countries around the world to efficiently grasp the presence and spread of the virus in local communities. This technology not only allows for rapid and non-invasive acquisition of epidemiological information on emerging infectious diseases for which clinical testing capacity is insufficient, but also makes it possible to capture asymptomatic infected individuals4,5).

According to sewage surveillance reported so far, no events have been observed that would change the interpretation of the data before or after the practical application of the SARS-CoV-2 vaccine3). In other words, the phenomenon of viral particles being excreted from the body as a result of SARS-CoV-2 vaccine administration has not been confirmed at the population level.

Vaccine shedding can occur with live attenuated strain vaccines (such as rotavirus vaccines), and it seems extremely difficult to logically explain the phenomenon of active ingredients being taken up by others in mRNA vaccines, including costaibe. It is difficult for RNA molecules to pass through mucous membranes and skin, and it is clear that they are quickly decomposed in the environment.

Self-amplifying mRNA vaccines are vaccines developed using new technology, and further research is essential to determine the long-term effects on health and the possibility of vaccine ingredient shedding. However, asserting unscientific views as if they were established facts seems to lack ethics and integrity. 

[References]

1) Japan Society of Nursing Ethics "Concerns about replicon vaccines being introduced for COVID-19 vaccinations: for yourself and those around you"

2) J Glob Health.2024:14:05005. PMID:38547496

3) Environ Int.2023:171:107718. PMID:36584425

4) PLOS Glob Public Health.2021;1:e0000061. PMID:34927170

5) Sci Total Environ.2020:749:141364. PMID:32836117

My comments

1. The basis is given as understanding the spread situation through sewage surveillance, but this does not allow for understanding of direct contact with the body surface (breathing on the body surface), sweat, exhaled air, blood, saliva, etc. → It is difficult to prove the existence of shedding, and at the same time, it is not possible to prove its absence. Therefore, it is important to understand the situation in the clinical field.
2. The Japanese Society of Nursing Ethics is thought to be conveying the voices of the field, that is, it seems to tell us that strange things were happening among nurses when vaccinated with m-RNA vaccine.
3. I myself have experienced several strange things happening to my body that I have never experienced before after performing surgery on m-RNA vaccine recipients, such as sudden severe headaches, coughs, fatigue, and fevers. The aspirated blood of these patients showed clear differences from those of non-vaccinated patients. Without exception, it had a characteristic appearance of coagulation, as if it was foaming.
4. Not only me, but the doctors involved in the surgery also experienced similar symptoms.
5. I wonder if this was shedding.
6. I believe that dismissing the voices of the field based on fragmentary evidence is not the attitude that a scientist should take.
7. I am a clinician, so I have a habit of thinking about things from the field, so please forgive me if I have been rude.

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